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Particularly for complex patients with multiple medical conditions
More melanin deepens tone and improves UV tolerance
They promote lipid, protein, and DNA oxidation, forming cytotoxic products such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which compromise mitochondrial DNA and disrupt electron transport, especially at complexes I and III (Wang et al., 2024)
Todays newsletter, with obesity expert and lecturer in physiology at Anglia Ruskin university Dr Simon Cork, is about what weve just learned, why it changes our understanding of semaglutides and whether it will mean they become more widely available
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